Quick thought:
Use the persona’s to create realistic use cases based upon the real user's needs that you understand based upon your research. Usability people often call these use cases “user journey maps.”
Now, when you design your app, website or software product to engage the person that has to use it every day-- around their tasks (and not merely to satisfy regulatory requirements) the end users/patients will find the information presented to be easy to understand, useful to them, and they will freely engage with your system.